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The success rate decreases remarkably if patients have symptoms refractory to PPI therapy, patients have atypical symptoms other than heartburn or acid regurgitation, there is poor documentation of objective evidence of reflux disease, or the procedure is performed by less experienced surgeons

When its time to sleep, turn off anything that makes light

Cold vials can create pressure imbalances during needle insertion and make the reconstitution process more difficult

While adequately powered for the primary outcome, 1415 patients per group is relatively small

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This sustained absorption profile makes shots well suited for routine maintenance and diagnosed deficiencies like pernicious anemia, particularly when only B12 replenishment is needed